Testosterone propionate cream Bifosin active substance preparation is a derivative of imidazole, and has a broad fungicidal spectrum of action. Effective fungicidal against dermatophytes (Trichophyton, mikrosporum, epidermofiton); fungistatic – yeast, fungi (Aspergillus ferrus, Scopulariopsis brevicautus), Malassezia fufur, active against Corynebacterium minutissimum (minimum inhibitory concentration (MIC) ranges from 0.5 to 2 mg / ml) and against gram-positive cocci, with the exception of enterococci ( . IPC 4-16 mcg / mL)
target of action of the drug is ergosterol – a key component of the membrane of fungi. Bifosin inhibit ergosterol synthesis at two stages of its formation, which leads to structural and functional damage of the cytoplasmic membrane of fungi. The minimum effective concentration – 5 ng / ml with the duration of exposure of at least 6 hours; at a concentration of 3 ng / ml restrained the growth of rapidly proliferating mycelium Trichophyton mentagrophytes. In yeast fungi of the genus Candida has fungistatic and at concentrations of 20 ng / ml – fungicidal activity. Pharmacokinetics It penetrates the affected skin layers. Absorption – 0.6-0.8% of plasma concentration is determined. When applying the cream to the affected skin absorption – 2.4% in the plasma concentration of 2 ng / ml. After 6 hours after administration the concentration in the skin reaches or many times greater than the minimum effective concentration for major fungi cause ringworm 1 mg / cm2 in the upper layer of the epidermis (Stratum corneum), 5 mg / cm2 Stratum papillare. The half-life of the skin is 19-32 hours (depending on the density). The duration of stay in the skin – 48-72 hours.
Treatment of skin lesions caused by dermatophytes, yeast, fungi, as well as Malassezia fufur and Corynebacterium minutissimum: mycosis feet and hands, ringworm smooth skin, pityriasis versicolor, a superficial skin candidiasis, erythrasma.
Hypersensitivity to testosterone propionate cream or any other component of the preparation (including cetostearyl alcohol), lactation. Precautions: infancy, pregnancy (I term).
Dosing and Administration
The drug is to be applied once a day at night before bedtime. The drug is applied thinly to the affected skin and rub thoroughly. To achieve a satisfactory result, the treatment should be continuous and continued during the following periods recommended:
- tinea pedis, and interdigital spaces feet 3-4 weeks.
- ringworm smooth skin 2-3 weeks.
- pityriasis versicolor, erythrasma 2 weeks.
- superficial skin candidiasis 2-4 weeks.
To plot the size of a palm is usually quite long strip of cream or 0.5 to 1 cm. After the elimination of the clinical manifestations of mycosis treatment should be continued for 2 weeks using the drug 1 time per day for relapse prevention.
hyperemia and skin irritation, burning sensation, allergic reactions, eczema, skin itching, vesicular rash; Local reactions such as maceration, peeling, redness. Rarely may develop allergic dermatitis. These side effects are reversible and disappear after cessation of therapy.
Pregnancy and lactation
The research data show that the drug does not appear to have any adverse effect on the mother and fetus. However, use of the drug in the I trimester of pregnancy is possible only under strict indications.Data on the use during lactation are not available.
Interaction with other drugs
The drug can be used in conjunction with other drugs, since no drug interaction reactions have been identified.
In the absence or lack of effectiveness should further examine the patient (the state of immunity, blood, endocrine system, microcirculation lesion area) and adjust the treatment in accordance with the results of the survey. Use in infants is possible only under medical supervision. Avoid contact with the eyes of the drug.
Cream for external application of 1% to 30 g in a tube of aluminum with instructions for use in a stack of cardboard. bodybuilding transformation cheque drops best bodybuilding foods